Other than transmissions, what goes wrong on Ford Escapes with 100k+ miles?

We just hit 105k miles on our 2014 Ford Escape (1.6L) and the transmission went out while we were visiting family about a thousand miles from home. We had the transmission rebuilt and everything was fine on the drive back; but that got me thinking: what's next? Are there other known issues that tend to affect these vehicles when the get over 100,000 miles?